At the cellular level, ageing is strongly associated with impaired mitochondrial bioenergetics, reduced NAD ⁺ availability, and disruptions in proteostasis. These processes are not independent; they are dynamically regulated within a broader physiological network. https://pmtstructure.com   The use of a Saccharomyces-derived matrix is grounded in the evolutionary conservation of core eukaryotic metabolic pathways, suggesting that structurally preserved biochemical inputs may interact with human cellular systems at the level of fundamental metabolic regulation. https://zenodo.org/records/19534062