#_3 We have solved the mystery of ageing[1]… Are you with us?
SCIENTIFIC FACT[2]. Biological aging starts at 30-35 years old. Age-related cognitive decline is associated with metabolic, vascular, and inflammatory changes, making it challenging to distinguish primary causes from secondary (downstream) effects. This study demonstrates that brain aging follows a specific progression, with the first stage occurring in middle age and coinciding with increased insulin resistance. Moreover, we show that brain areas that age fastest are also those most vulnerable to neuronal insulin resistance. Importantly, we find that administering ketones, which can fuel neurons while bypassing insulin resistance, reverses brain aging effects. [1] https://drive.google.com/file/d/1hWwH_OXSZDeLQn-TRN2ayDYuMi7VFHHJ/view?usp=share_link [2] https://www.pnas.org/doi/10.1073/pnas.2416433122