The immune system in the brain is not only a ‘defence’ but also a regulator of emotional state.
Scientific Insight (2025)
Recent findings indicate that microglia, the brain’s immune cells, exist in distinct subtypes. Some subtypes enhance anxiety-like behaviour, functioning as an 'accelerator', while others counteract it, acting as a 'brake'. This discovery highlights the role of immune mechanisms in neural stability.
Neuro-Immune Mechanism of Ageing
Ageing is characterised by systemic low-grade inflammation, immune imbalance, mitochondrial decline, and impaired cellular regulation. Microglia respond to these systemic alterations and influence brain resilience, stress response, and ageing trajectories.
Systemic Determinants of Microglial Behaviour
Microglial function is shaped by whole-body physiology, including metabolic efficiency, inflammatory markers, oxidative stress, circadian stability, and physical activity patterns. These systemic factors define the regulatory environment of the neuro-immune axis.
Position of the OMARIDINTM System
The OMARIDINTM system enhances systemic physiology and reduces inflammatory load. This creates a favourable biological environment for balanced microglial activity—an emerging determinant in neural ageing and stress response regulation.
Key Mechanistic Link
By targeting upstream physiological processes, OMARIDINTM indirectly supports downstream neuro-immune stability. This aligns with modern scientific understanding of ageing as a multi-system, interconnected process.
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Primary sources;
https://www.sciencedaily.com/releases/2025/11/251113071604.htm
