Brain acidity and neurological disorders.

Researchers have found a link between brain metabolic problems and a number of neuropsychiatric and neurodegenerative diseases[1], such as autism and Alzheimer's disease. This is the first and largest systematic study to evaluate pH and lactate levels[2] in the brain in various animal models.

It is noted that about 30 percent of the 2,294 animals studied in 109 different samples showed significant changes in pH and lactate levels. This means that such disorders are characteristic of many neuropsychiatric diseases.

In animal models representing depression caused by stress, diabetes, or colitis, a consistent pattern of decreased brain pH and increased lactate levels was observed.

In autism models, different reactions were observed: some showed an increase in pH and a decrease in lactate levels, while others showed the opposite pattern.

And in behavioural tests, the team noted a strong link between high lactate levels and impaired working memory. At the same time, lactate production is necessary for memory formation, so a decrease in its level can also contribute to dysfunction.

Scientists have concluded that changes in brain pH and lactate levels may be biological markers of neuropsychiatric disorders accompanied by cognitive impairment.

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